Matrix Metalloproteinases Essay -- Biology, Science Experiments

Matrix metalloproteinases are members of a large family of enzymes that tummy degrade extracellular matrix as well as some other molecules 1. MMPs participate in a broad variety of normal and unhealthy states 2, and vex been implicated as potential mediators of cardiac dilation and optic failure. Indeed, in culture cells 3,4, animal models mimicking the CHF syndrome 5,6 and CHF patients 7-9, a mechanistic relationship has been present respect to myocardial MMP verbiage and left ventricular (LV) remodeling process 3-9. Likewise, late(a) reports on endothelial culture cells 10-12 and animal models of CHF 13,14 have shown that the increase of expression and activity of MMP-2 and MMP-9 (called gelatinases) might also play an important role in the impairement of endothelial function, a key event contributing on morbidness and mortality in CHF patients 15. However, data respect to the role of MMPs on endothelial dysfunction in the setting of human CHF is completely unknown. Therefor e, the aim of this determine was to assess the association between the activity of gelatinases and endothelial dysfunction in patients with CHF. We hypothesized that a higher plasma MMP-2 and MMP-9 activities correlate with a lower endothelial function in patients with CHF.We included CHF patients, NYHA functional class II-III controlled in a university clinical center. All patients signed an informed consent approved by our institutional Review Board and Ethics Committee. Inclusion criteria were left ventricular ejection fraction (LVEF) ...esented here share new clinical essay suggesting a possible participation of MMP-2 and MMP-9 in the genesis and progression of endothelial dysfunction, suggesting an active role of MMPs in this event. The main limitations of the present study were the particular number of patients, the presence of standard pharmacological therapy administered that may influence our results and much(prenominal) a correlations reported here did not demostrate a cause-effect relationship, but in that location is experimental evidence that could sustain our results. Further studies are clearly required to address this issue for exploring the causal relationships between these proteases and the pathophysiology of endothelial function.AcknowledgementsThe authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International journal of Cardiology 20.